Which Patients are Appropriate for PillCam® COLON?
19 to 24% of patients needing endoscopy are at higher risk of complications from the procedure; specifically, individuals on blood thinning agents or who present a sedation risk may be more likely to experience a serious cardiopulmonary event during or following the procedure.1,2,3 By offering the proven benefits of an endoscopic capsule, PillCam COLON allows for a safe, reliable, and clinically-proven diagnosis for patients with:
Patients on anticoagulant and antiplatelet therapy have an increased risk of thromboembolic adverse events including coronary stent thrombosis, myocardial infarction, stroke, and death when drugs are withheld even for a short period of time.4
PillCam COLON gives physicians the option of a first-line diagnostic exam procedure without interrupting medication regimes. Medication would only need to be withdrawn or adjusted if a second, therapeutic exam is necessary.
Patients at greater risk for respiratory distress or pulmonary events associated with procedural sedation.
PillCam COLON gives physicians the option of a first-line diagnostic exam procedure that requires no sedation. If a therapeutic exam is necessary, patients could then have a second procedure where sedation is administered or undergo a non-sedated therapeutic procedure.
5-10% of colonoscopy procedures do not allow full visualization of the cecal cap due to difficult anatomy, increased risk of perforation, or patient discomfort, thus increasing the likelihood of missed pathology.5
Patients for whom the goal of examination is to judge the extent and severity of colonic mucosal inflammation.
“Colon Capsule Endoscopy with PillCam COLON is a safe and well-tolerated procedure. Data show encouraging detection accuracy of active UC and substantial agreement with colonoscopy. The high acceptability of PillCam COLON allows noninvasive monitoring of disease activity in UC patients.”6
In patients with proven or suspected IBD, colon capsule endoscopy is an effective diagnostic modality since it is minimally invasive and can assess disease activity, which often helps to guide treatment strategies.7
Patients Who Refuse Colonoscopy
Patients who refuse a colonoscopy for a variety of reasons including anxiety, fear, or embarrassment.
PillCam COLON could be offered as a second procedure option to patients and then a therapeutic exam could be utilized thereafter if an abnormality is found.
• 49% of patients expressed interest in use of PillCam COLON when given the choice between colon capsule endoscopy, colonoscopy, stool test, and no test at all (among US individuals non-compliant with physician-recommended colonoscopy colorectal cancer screening).8
• Almost 80% of colonoscopy non-compliant patients are completely willing to undergo colonoscopy if a polyp is discovered using PillCam COLON.9
1 Rutter C. Adverse events after screening and follow-up colonoscopy. Cancer Causes Control (2012) 23:289-296.
2 Campbell E. Automated before-procedure electronic health record screening to assess appropriateness for GI endoscopy and sedation. Gastrointestinal Endoscopy 2012: In Press.
3 Given Imaging sponsored, multi-national survey of 303 GI physicians who estimated the percentage of large bowel
examinations with patients having high bleeding risk or high sedation risk.
4 Johnson D. Antithrombotic Agents and Endoscopic Procedures. Medscape Gastroenterology Viewpoints. Jan 2010.
5 Waye, J., Rex D., Williams C. Colonoscopy Principles and Practice Second Edition. Chichester : Blackwell Publishing, 2009.
6 Sung J, ICCE Workshop Report 2008 Vol 6, page 4, GMB-0331-01.
7 Majumdar D et al, PillCam COLON Capsule is an Effective Tool in Management of Patients with Suspected or Known Inflammatory Bowel Disease. Abstract Tu1201, DDW 2011.
8 Rex D, Lieberman D, A Survey of Potential Adherence to Capsule Colonoscopy in Patients Who Have Accepted or Declined Conventional Colonoscopy”. J Clin Gastroenterol 2012; In Press.
9 Mason D et al, “A survey of potential adherence to conventional colonoscopy with positive capsule colonoscopy findings in patients who have declined colonoscopy”. 2012 Dialogue for Action on Colorectal Cancer Screening, March 21-23, 2012.